A HARMONIZED PROTOCOL FOR HIPPOCAMPAL VOLUMETRY: AN EADC-ADNI EFFORT

Protocol definition

Boccardi M, Bocchetta M, Apostolova LG, Barnes J, Bartzokis G, Corbetta G, DeCarli C, deToledo-Morrell L, Firbank M, Ganzola R, Gerritsen L, Henneman W, Killiany RJ, Malykhin N, Pasqualetti P, Pruessner JC, Redolfi A, Robitaille N, Soininen H, Tolomeo D, Wang L, Watson C, Wolf H, Duvernoy H, Duchesne S, Jack Jr CR, Frisoni GB, for the EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation. Delphi Definition of the EADC-ADNI Harmonized Protocol for Hippocampal Segmentation on Magnetic Resonance. Alzheimer's & Dementia, 2015;11(2):126–138.

Concurrent validation and analysis of the sources of variance

Frisoni GB, Jack CR, Bocchetta M, Bauer C, Frederiksen KS, Liu Y, Preboske G, Swihart T, Blair M, Cavedo E, Grothe MJ, Lanfredi M, Martinez O, Nishikawa M, Portegies M, Stoub T, Ward C , Apostolova LG, Ganzola R, Wolf D, Barkhof F, Bartzokis G, DeCarli C, Csernansky JG, deToledo-Morrell L, Geerlings MI, Kaye J, Killiany RJ, Lehéricy S, Matsuda H, O’Brien J, Silbert LC, Scheltens P, Soininen H, Teipel S, Waldemar G, Fellgiebel A, Barnes J, Firbank M, Gerritsen L, Henneman W, Malykhin N, Pruessner JC, Wang L, Watson C, Wolf H, deLeon M, Pantel J, Ferrari C, Bosco P, Pasqualetti P, Duchesne S, Duvernoy H, Boccardi M for the EADC - European Alzheimer’s Disease Consortium and the ADNI - Alzheimer’s Disease Neuroimaging Initiative. The EADC-ADNI Harmonized Protocol for Hippocampal Segmentation on Magnetic Resonance: Evidence of Validity. Alzheimer's & Dementia, 2015;11(2):111–125

Validation versus pathology

Apostolova LG, Zarow C, Biado K, Hurtz S, Boccardi M, Somme J, Honarpisheh H, Blanken AE, Brook J, Tung S, Ng D, Alger JR, Vinters HV, Bocchetta M, Duvernoy H, Jack CR, Frisoni GB, for the EADC-ADNI Working Group on the Harmonized Protocol for Manual Hippocampal Segmentation. Relationship Between Hippocampal Atrophy and Neuropathology Markers: a 7T MRI Validation Study of the EADC-ADNI Harmonized Hippocampal Segmentation Protocol. Alzheimer's & Dementia. 2015;11(2): 139–150.